A Crucial Role for Mmp-2 in Osteocytic Canalicular Formation and Bone Metabolism

From the Laboratory for Behavioral Genetics 1 , RIKEN BSI, Wako, Saitama 351-0198, Japan; the Department of Molecular Pharmacology 2 , Medical Research Institute, and Center of Excellence Program for Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical & Dental University, Chiyoda, Tokyo 101-0062, Japan; the Department of Molecular Immunology 3 , Graduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyo, Tokyo 113-8657, Japan; the Division of Biochemistry and Molecular Biology 4 , Department of Functional Biology, Kanagawa Dental College, Yokosuka, Kanagawa 238-8580, Japan; the Discovery Research Laboratories 5 , Shionogi & Co., Ltd., Toyonaka, Osaka 561-0825, Japan; and the Center for Immunology and Inflammatory Diseases 6 , Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02129 Running Title: MMP-2 in Bone Homeostasis Address correspondence to: Shigeyoshi Itohara, Laboratory for Behavioral Genetics, RIKEN BSI, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan, Tel. +81-48-467-9724; Fax. +81-48-467-9725; E-Mail: [email protected], and Masaki Noda, Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical & Dental University, 2-3-10 Kanda-Surugadai, Chiyoda, Tokyo 101-0062, Japan, Tel. +81-3-5280-8067; Fax. +81-3-5280-8067; E-Mail: [email protected]